(Metabolic Regulation and Signal Transduction)

Catalog Data: This course is a continuation of Biochemistry I, providing a comprehensive introduction to the study of metabolic pathways with emphasis on basic principles of regulation.  The mechanism of hormone action, membrane transport, and interrelationships between signal transduction and metabolic regulation will be discussed.  The course will conclude with an introduction to molecular biology including DNA replication, transcription, and translation.  Offered in the spring semester.  One semester, three credits.

Prerequisite: CHEM 315, 315L .

Textbooks:
1. Biochemistry, Fourth Edition, by D. Voet & J. G. Voet; John Wiley & Sons, Inc., 2011. ISBN: 9780470570951 .
2. Biochemistry Laboratory: Modern Theory and Technique, by Rodney Boyer, Benjamin Cummings, 2006;  ISBN: 9780805346138 .

Calculator Policy: Scientific Calculator required

Goals: The course is designed to:
1) introduce students to the basic concepts required for the study of metabolism and molecular biology and
2) provide an in-depth study of metabolism and signal transduction with an emphasis on regulatory mechanisms.

Topics: Note: The sequence of major topics that will be covered this semester are listed below. Rate and sequence of coverage of material may vary from the schedule. Reading assignments are given in parentheses following the topic(s) and refer to the textbook. Additional reading assignments will be made during the course of the lecture.

Overview of Metabolism (Chapter 16)
Isotopes in Biochemistry (Chapter 16)
Carbohydrates and Glycolysis (Chapters 11 and 17)
Glycogen Metabolism (Chapter 18)
Citric Acid Cycle (Chapter 21)
Oxidative Phosphorylation (Chapter 22)
Signal Transduction (Chapter 19)
Special Topics in Carbohydrate Metabolism (Chapter 23)
Photosynthesis (Chapter 24)
Membrane Transport (Chapter 20)
Lipids and Lipid Metabolism (Chapters 11 and 25)
Amino Acid Metabolism (Chapter 26)
Nucleotide Metabolism (Chapter 28)
Nucleic Acid Structures (Chapter 29)
Replication, Transcription, and Translation (Chapters 30, 31, and 32)

Grading: 
4 hour tests @ 100 points each 400 points
Homework 50 points
Final Examination 150 points 
TOTAL: 600 points

Final Examination:  Comprehensive

Resources:  CBU Internet resources

Attendance: Regular class attendance is expected.

Coordinator: Dr. Dennis Merat