Welcome to the Minority Health and Health Disparities International Research Training (MHIRT) Program at CBU.

Brazil - Locations: Belem, Curitiba, Florianopolis, and Sao Paulo.

Curitiba: One laboratory, 2 student positions available (Preferably 1 graduate/medical student)

Project description:  Clinical, biological and molecular aspects of childhood adrenocortical tumors: relationship between therapeutic response and prognosis.  Development of a wide range screening tool to identify adenocarcinoma in newborn infants.  Techniques used in this research clinical database analysis, Western blots, and molecular biology techniques.

2008 Project Title: DNA Extraction from Paraffin Embedded and Frozen Adrenocortical Tumors.

Site mentor: Dr. Bonald C. Figueiredo, Department of Pediatrics and Chemistry, Clinical Director of Pediatric Oncology, Universidade Federal do Parana

Recent mentor publications:

• West, N.A.; Ribeiro, R.C.; Jenkins, J.; Rodriguez-Galindo, C.; Figueiredo, B.C.; Kriwacki, R.; Zambetti G.P. Identification of a Novel Germline Variant Hot Spot Mutant p53-R175L in Pediatric Adrenal Cortical Carcinoma. Cancer Res. 2006 May 15;66(10):5056-5062.

• Pianovski, M.A.D.; Cavalli, L.R.; Figueiredo, B.C.; Haddad, B.R.; Zambetti, G.P.; Ribeiro, R.C.; Lalli, E. SF-1 Overexpression in Childhood Adrenocortical Tumors. Eur J Cancer. 2006 May;42(8):1040-1043.

• Zancanella, P.; Pianovski, M.A.D.;  Oliveira, B.H.; Ferman, S.; Custodio, G.; Lichtvan, L.C.I.; Voss, S.Z.; Stinghen, S.T.; Callefe, L.G.; Parise, G.A.; Santana, M.H.A.; Figueiredo, B.C. Mitotane Associated With Cisplatin, Etoposide and Doxorubicin in Advanced Childhood Adrenocortical Carcinoma: Mitotane Monitoring and Tumor Regression. (2006), Journal of Pediatric Hematology and Oncology. 2006;28(8):513-24.