BIOL 103: BIOLOGY OF ADDICTION
Spring 2009
Course Descriptions and Syllabi for lecture and laboratory components
Updated April 28, 2009
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FINAL EXAM FOR BOTH LECTURE AND LABS: FRIDAY, MAY 8: 10:30 A.M. TO 12:30 P.M.
FORMATS: ·
LECTURE: Short answer, multiple-choice, matching. NO ESSAYS; ·
LAB: Identification, multiple-choice, matching, short
answer. NO ESSAYS. Results
of chocolate experiment:
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Speaker Schedule |
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Monday, April 27 Lauren Phillips |
Wednesday, April 29 Danielle Howell |
Friday, May 1 Brandi Sims |
Monday, May 4 Jennifer Hiltonsmith |
To the web supplement: http://www.cbu.edu/~seisen/B103.html
Course Description for BIOL 103: Alcohol and Drug Abuse
In this course, we will
cover the biological effects of alcohol and drugs on human organ systems,
particularly the nervous, digestive, excretory and reproductive systems. We
will discuss the psychological and sociological consequences of these effects.
The use of drugs in both therapeutic and pathologic situations will be
explored. Modalities of recovery will be discussed. This course fulfills the
university graduation requirement for a science course with a lab. Three (3)
credits, offered in the Spring semester.
For the laboratory component, you
must be comfortable with the idea of holding, observing, and dissecting
preserved organs and animals, specifically sheep brains, sheep hearts, ox eyes,
human brains, and fetal pigs. You must
also be comfortable with the idea of working with live animals, specifically Drosophila melanogaster.
The lecture class meets MWF 1:00 to 1:50 p.m., while the laboratory sections meet on Mondays and Tuesdays, from 2:00 to 4:50 p.m. The textbook we will use is Eisen (2009), The Biology of Addiction, and the lab book we will use is Eisen (2009), Laboratory Workbook for BIOL 103, both available at the bookstore.
Grading in the lecture component will be on the basis of the following:
1)Short, weekly quizzes, usually given in the first 10 minutes on Fridays, covering the previous week’s material. Collectively, these quizzes will count 1/6 of your final grade;
2) 3 semester exams, each worth 1/6 of your final grade. All exams are comprehensive;
3) A 10-minute oral presentation on the topic of the biology of addiction as it relates to either your major or your career choice. Oral presentations will be scheduled during the last 4 meetings of the class. Please submit an outline of your presentation and 5 multiple-choice questions pertaining to your presentation at least 2 days in advance, so that I can print enough copies of the outline for distribution to the rest of the class. This presentation will count 1/6 of your final grade;
4) A comprehensive final exam scheduled during final exam week, worth 1/6.
Grading in the laboratory component will be on the basis of the following:
- 2 laboratory reports, each worth 1/5 of your final grade;
- Weekly quizzes, collectively counting 1/5 of your final grade;
- A Midterm Exam, worth 1/5 of your final grade;
- A comprehensive final exam, worth 1/5 of your final grade.
Please note that there are two weeks
in the Spring 2009 semester for which Monday classes are cancelled: January 19 (Martin Luther King Day) and April
13 (extended Easter weekend). Students
enrolled in the Monday lab are expected to make up these lab meetings by either
attending the Tuesday labs or by attending a make-up lab on the Friday of those
respective weeks, i.e. January 21 and April 17.
Tests and laboratory reports will be graded on a 4-point scale, and final grades will be given on the basis of the following scale:
3.50 - 4.00 = A
2.75 - 3.49 = B
2.00 - 2.74 = C
1.00 - 1.99 = D
<1.00 = F
Some Useful Web Addresses:
The National Institute on Alcohol Abuse and Alcoholism -
http://www.niaaa.nih.gov/
GUIDELINES FOR LABORATORY REPORTS
- Please DOUBLE-SPACE your laboratory report, and use margin size to 1 inch.
- Place a cover sheet at the
front of your laboratory report. The cover sheet should have your name,
the report title, the course and section numbers centered on the page.
PLEASE
The laboratory report should include the following sections:
- An ABSTRACT section, in which you describe in briefest form, the purpose, primary results and conclusions of the research report. By convention, it is 200 words or 3% of the laboratory report, whichever is LESS;
- An INTRODUCTION section, in which you provide information pertaining to the problem as it is recognized and in which you discuss background information which would be pertinent to the reader. The purpose, in which you specify the questions to be addressed in THIS lab report, should be in the LAST paragraph of the introduction section;
- A MATERIALS AND METHODS section, in which you discuss the organism(s) under study and the experimental protocol in "text" form. PLEASE DO NOT INCLUDE A MATERIALS LIST. If there are several parts to the experiment, each part should be described separately. Briefly describe in the text of your Materials and Methods section the protocol you followed in conducting this experiment;
- A RESULTS section, in which you discuss the data from each part of the study in the same sequence as the parts were described in the Materials and Methods section. Use a paragraph to tell the reader what the main point is, and at the end of the sentence, refer to a specific Table or Figure, as in the following: "Seedlings exposed to either .1% or .2% phosphate grew vigorously, but the controls did not (Figure 1)." It is essential to convert or present the data in an understandable format. CHARTS OF RAW DATA ARE NEITHER NECESSARY NOR DESIRABLE!;
- A DISCUSSION section, in which you relate the results of your experiment to the general body of knowledge pertinent to this area of research;
- A REFERENCES section, in which you list the references used for background information and/or protocol procedures, including your laboratory textbook. Only journal articles from refereed journals or government agency reports (e.g. NIDA) are permitted. References to web pages are NOT permitted.
CRITERIA FOR THE GRADING OF PAPERS AND EXPERIMENTAL REPORTS
The maximum grade is a 4.00 and is a composite of three grades based on spelling grammar, and content.
I. Spelling counts 10% of the total grade. Each different spelling or typographical error will usually result in a point deducted from the maximum. However, if one word is consistently misspelled, it will be deducted only once. Low grades in spelling can be avoided by keeping a dictionary on hand and proofreading your work before you submit it for review.
II. Grammar counts 20% of the total grade. Each grammar error (wrong tense, poor sentence of paragraph structure) will usually result in a point deducted from the maximum. Low grades in grammar can be avoided by proofreading your work before you submit it and by writing practice essays.
III. Content counts 30% of the total grade. The kinds of questions that are considered in evaluating content include the following:
- Is your information accurate?
- Is your discussion logical?
- Did you transform the raw data into a more useful and appropriate format?
- Do you adequately support your argument?
- Do you adequately correlate and contrast your data to previous experience?
- Do you support your conclusions with the appropriate statistical test(s)?
IV.Format counts 40% of the total grade. The kinds of questions that are considered in evaluating format include the following:
- Did you follow the appropriate protocol for writing the report?
- Are all section of the lab report complete?
- Did you transform the data into an appropriate manner?
- Did you include the appropriate tables and figures?
You should write your reports as if you were submitting them to the Transactions of the Tennessee Academy of Sciences. I, in turn, will review them as if I were an editor for the journal.
Grades
Spelling x 10% = ____________.
Grammar x 20% = ___________.
Content x 30% = ____________.
Format x 40% = _____________.
COMPOSITE GRADE ._______
BIOL
103: Alcohol & Drug Abuse
Spring 2009
Lecture Schedule
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Day/
Date |
Topic (Chapter in book) |
That week’s Exercise in Laboratory Manual (includes
Monday & Tuesday labs)** |
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M 1/12 |
Risk factors (1); Close to Home: Part I.
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1. Diffusion |
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W 1/14 |
Risk factors, cont’d (1) |
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F 1/16 |
Basic Neuroanatomy and Physiology,
cont’d (2) Structure of neurons, and how neurotransmitters work, Neurobiology animations |
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M 1/19 |
Martin
Luther King Day – No class |
5. Nervous system |
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W 1/21 |
Basic Neuroanatomy and Physiology,
cont’d (2): Simple reflexes; Brain structure and function |
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F 1/23 |
Basic Neuroanatomy and Physiology,
cont’d (2): Autonomic function |
Special
make-up lab for Jan. 19 |
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M 1/26 |
Basic Neuroanatomy and Physiology, cont’d (2): Senses |
3. Microscopy |
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W 1/28 |
Reward Circuits and Pathways (3): Close to Home: Part II |
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F 1/30 |
CRF, the HPA axis, and the tendency towards relapse (4) |
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M 2/2 |
Genetics of Addiction (5):
Fundamentals of genetics |
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W 2/4 |
Genetics of Addiction (5): Genes implied or involved in affecting
behaviors relating to addiction. |
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F 2/6 |
Brain imaging (6) |
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M 2/9 |
Lecture Exam 1 |
2. Enzymes |
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W 2/11 |
Pharmacokinetics and physiology (7) Structure & Function of the excretory system Drug metabolites Commercial drug testing kits Attainment of Steady State: |
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F 2/13 |
Ethanol, (8): Mode of action, metabolism, and toxicity “Beer goggle” Effect: http://www.youtube.com/watch?v=1gvgAy76aGs Alcoholic Vervet Monkeys! - Weird Nature - BBC
animals http://www.youtube.com/watch?v=pSm7BcQHWXk Dean Martin and http://pageperso.aol.fr/marcbrecy/deanmartin.html How not to rob a liquor store MO, Metabolism & Toxicity of Alcohol |
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M 2/16 |
Ethanol, cont’d (8): Liver
transplant surgery “Wet brain” syndromes |
4. Anatomy of Internal organs: Dissection of fetal pig |
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W 2/18 |
Ethanol, cont’d (8) Fetal Alcohol Syndrome |
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F 2/20 |
Drug testing protocol (9) Depressants (10): Benzodiazepines |
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M 2/23 |
Depressants (10): Barbiturates |
6. Respiratory system; |
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W 2/25 |
Depressants (10): Inhalants and anesthetics David
after Dentist: http://www.youtube.com/watch?v=txqiwrbYGrs&NR=1
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F 2/27 |
Psychostimulants (11): Cocaine and amphetamines (10) |
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M
3/2 |
Psychostimulants (11): Amphetamines and Methylphenidate Faces of meth |
MIDTERM
EXAM |
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W 3/4 |
Lab Midterm Exam Answer Key: Nicotine (12) |
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F 3/6 |
***EXAM 2*** |
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M-F 3/9-3/13 |
SPRING BREAK |
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M 3/16 |
Opioids (13) |
12. Excretory system |
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W 3/18 |
Marijuana/Cannabis (14) |
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F 3/20 |
Psychedelics (15) |
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M 3/23 |
Anabolic/Androgenic Steroids (16) |
9. Effects of selected drugs on Daphnia
magna, a micro- crustacean.
I. |
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W 3/25 |
Food compulsions (Caffeine/chocolate) (17) |
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F 3/27 |
Problem and Pathological gambling
(18) Top 10 best gambling songs, according to Virgin records: Kenny Rogers – The Gambler The Clash – Three card trick Electric Light Orchestra – Poker Frank Sinatra – Luck be a Lady Motorhead – Ace of Spades |
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Summary of drug effects: http://learn.genetics.utah.edu/content/addiction/drugs/mouse.html
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M 3/30 |
Behavioral compulsions (19): Exercise bulimia PSA about anorexia: |
10. Ethanol.
I. Effects on humans: Gross anatomy of liver 11. Ethanol.
II. Effects on Drosophila melanogaster Optional initial draft of lab report on
effects of ethanol on human due. |
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W 4/1 |
Behavioral compulsions (19):
Cybersex |
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F 4/3 |
LECTURE EXAM 3 |
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M 4/6 |
Behavioral compulsions (19):
Serial killing Timeline of “It was like a brick wall dropped in front of me”: |
7. Tar content of selected cigarettes Lab report on ethanol effects on human due. |
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W 4/8 |
***NO CLASS*** |
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Th 4/9 |
Easter Break |
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F 4/10 |
Easter Break |
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M 4/13 |
Easter Break |
8d. Effects of caffeine on the circulatory
system. Volunteers can be under 21. Those who do not volunteer will assist. Lab report on ethanol effects on fruit
flies due. |
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W 4/15 |
NO
CLASS – Passover VII |
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F 4/17 |
Treatment modalities (20): Medical treatment |
Special
make-up lab for M 4/13 |
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M 4/20 |
Treatment modalities (21): Complementary
and alternative medicine; Support groups, and the treatment center
experience. |
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W 4/22 |
Prevention (21): Vaccines |
12. OK, OK,
what about chocolate? Gender-specific
differences; OR Impact of alcoholism and drug abuse to economy and status of |
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F 4/24 |
Prevention (21): Communication and education If you
were around in 1919, (just before prohibition started) and came upon the
following poster... |
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M 4/27 |
Student presentations |
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W 4/29 |
Student presentations |
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F 5/1 |
Student presentations |
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M 5/4 |
Student presentations |
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T 5/5 |
Study Day |
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Final exams for lecture and lab will be given during
Final Exam Week. |
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![[]](BIOL103LcLbDesc_files/image002.jpg)
**Schedule of labs is subject to change, due to scheduling of Martin
Luther King Day (Monday), and Easter