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Caduceus
Newsletter: Summer 2008.03, July Dr.
Stan Eisen, Director Home
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Caduceus
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Table of Contents: |
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1. Summer Research by Michelle Paul at Saint Jude
Children’s |
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Identification of
synergistic antimalarial drugs As part of the Pediatric
Oncology Education program at St. Jude Children’s We are using two approaches in
our attempt to identify synergistic drug pairs. The first is based on a modified fixed
ratio isobologram method. This method
involves mixing selected compounds at different ratios and determining the
fractional inhibitory concentration based on both the IC50’s of the drugs in
combination and alone. Based on
calculations, we can determine whether the compounds are synergistic,
additive, or antagonistic in combination with each other. Growth inhibition will be measured by the
DNA content of the parasites in the red blood cells using two DNA binding
fluorescent dyes. Fluorescence is then
measured by the EnvisionTM spectrophotometer. The second approach uses a high throughput
screening method that involves identifying compounds from St. Jude’s library
of 3160 bioactive drugs that, when mixed with a single concentration of chloroquine,
exhibit a substantial increase in activity.
Our measurements of the growth inhibition in this approach are based
on an automated growth inhibition assay preformed in a BSL-2 deck using one
of the robots of the CBT department at St. Jude Children’s One of the most important factors in malaria treatment options is cost, due to the economic status of the population affected by the disease. Our hope is that one of these two approaches will yield a combination of two drugs that is synergistic with one another. The possible benefits of a synergistic combination treatment are smaller doses (hopefully leading to fewer side effects) and more cost efficient means of treatment. Michelle Paul Pediatric Oncology Education Program Department of Chemical Biology and Therapeutics St. Jude Children’s Here’s a picture of Michelle with “the robot”:
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2. ====
AAMC STAT ====, News from the Association of American Medical Colleges,
June 2, 2008 edition. |
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== AAMC launches new debt management program == Nominations sought for resident community service award == Women in Medicine program seeks award nominations, poster submissions == NIH awards next round of clinical, translational research grants == On the move ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^ AAMC launches new debt management program The AAMC has launched a new debt management initiative called FIRST for Medical Education. FIRST offers a full range of financial information, resources, services, and tools for applicants, medical school students, residents, advisors, and financial aid officers (FAOs). The program, developed with input from the AAMC Group on Student Affairs Committee on Student Financial Assistance and the Organization of Student Representatives, aims to help medical school students expand their financial literacy, make smart decisions about student loans, and manage their student debt wisely. The FIRST program offers a Web site with a number of resources including: "First Facts," short, informational sheets on a variety of financial aid related topics; an FAO Lender Assessment Tool for financial aid administrators to sort survey data based on loan industry-related criteria in order to compare various loan programs; and a new Economic Hardship Deferment Calculator for medical students and residents to estimate eligibility for deferment. Future phases of FIRST will include streaming video, podcasts, a comprehensive debt management curriculum and additional Web-based tools. Information: Go to http://www.aamc.org/programs/first/ ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^ Nominations sought for resident community service award The AAMC Organization of Resident Representatives (ORR) is seeking nominations for the 2008 Resident Community Service Recognition Award. This annual award is given to a resident physician who has demonstrated a commitment to community service above and beyond the rigors of residency training to serve the needs of the community. Residents enrolled at any AAMC-member institution are eligible for nomination. The award will be presented at the association's annual meeting on Nov. 1. The award includes a $1,000 contribution to the recipient's non-profit charity of choice. Nominations are due June 30. Information: http://www.aamc.org/members/orr/communitysvcaward.htm ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^ Women in Medicine program seeks award nominations, poster submissions The AAMC Women in Medicine program is seeking nominations for the 2008 Women in Medicine Leadership Award. The award recognizes individual and organizational contributions to advancing women leaders in academic medicine. Any member of the academic medicine community may nominate one individual or organization for the award, which will be presented during the association's annual meeting in Information: Go to http://www.aamc.org/members/wim/award.htm The Women in Medicine program is also soliciting submissions of abstracts and posters to be presented at the AAMC annual meeting. AAMC Women Liaison Officers, faculty affairs professionals, directors of diversity programs, leaders of professional societies, and other leaders in academic medicine are encouraged to submit abstracts. Submissions are due June 6. Information: Go to http://www.aamc.org/members/wim/08callforposters.pdf ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^ NIH awards next round of clinical, translational research grants Fourteen research institutions have been accepted into the National Institutes of Health's (NIH) Clinical and Translational Science Award (CTSA) consortium. Together these institutions will receive $533 million over five years as they work to reduce the time it takes for laboratory discoveries to become patient treatments and to engage communities in clinical research efforts. The 2008 awardees are: Albert Einstein College of Medicine of Research Institute; Antonio; and institutional members of the consortium. Information: Go to http://www.ncrr.nih.gov/ctsa2008 ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^ On the move Paul Rothman, M.D., has been named dean of the Lucille A. Carver College of Medicine, effective immediately. He has served as head and professor of internal medicine at the UI Carver College of Medicine and UI Hospitals and Clinics since 2004. He succeeds Jean Robillard, M.D., who is stepping down from the deanship to focus on serving as UI vice president for medical affairs. Francis S. Collins, M.D., Ph.D., will step down as director of the NIH's National Human Genome Research Institute, effective Aug. 1. He has served in this position since 1993, and now intends to explore writing projects and other professional opportunities. Dr. Collins is credited for leading the Human Genome Project, a public effort to sequence the human genome. ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^ Academic Medicine Online Biomedical research has unlimited potential to advance the science and practice of medicine, but how do we best teach tomorrow's investigators to identify and address the ethical, legal, and social implications of their research? In two commentaries, Ezekiel Emanuel, M.D., Ph.D., chair of the department of bioethics at the National Institutes of Health's Clinical Center, and Judith A. Salerno, M.D., executive director of the Institute of Medicine, examine the issue of bioethics education in the June issue of Academic Medicine. ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^ |
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3. Received
this week (mostly from the recent biennial NAAHP convention in |
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· DVD – The Art of Medicine, The Power of Science, describing the Medical Scientist Training Program at UAB. · Viewbook 2008-09 · Profile 2007-2008 · College of Pharmacy and Health Sciences Viewbook |
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4. For
those of you applying to health-related graduate programs and have NOT
filled out an Evaluation Request Form, PLEASE DO SO NOW. |
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Please print the following form, fill it out, sign it, and then send it back to me: ---------------------" PREPROFESSIONAL EVALUATION REQUEST FORM In order to facilitate the collection of evaluations written on your behalf, please fill in the top half of this evaluation request form. YOUR
NAME________________________
UNIVERSITY ID # 899- STREET ADDRESS___________________________ MAJOR _____________________ CITY, STATE ZIP CODE . E-mail address Telephone number where you can be reached PROGRAM TO WHICH YOU ARE APPLYING__________________ Applicants to medical school: AMCAS # _____________ The Family Educational Rights and Privacy Act of 1974 and its amendments guarantee students access to their educational records. Students, however, are entitled to waive their right of access concerning recommendations. The following signed statement is the applicant's wish regarding this recommendation. (Please check one box.)
o I waive my right to inspect the contents of this recommendation. o I do not waive my right to inspect the contents of this recommendation. Signature Date Please write down the names (and addresses if they are off-campus) of people to whom you want evaluations sent. (Do not fill in the "Date sent" or "date received" blanks.)
Please indicate the names and addresses of programs to which you plan on applying. (Do not fill in the spaces in the grey columns. Add more sheets if necessary.)
-----------------------" |
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5. Marginalia: Weekly food consumption in selected
countries |
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Very Interesting …
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Dr. Stan Eisen,
650
E-mail: seisen@cbu.edu
http://www.cbu.edu/~seisen/
Caduceus Newsletter Archives: http://www.cbu.edu/~seisen/Caduceus.html